I have definitely used ibuprofen as a prophylaxis for pain for both marathons and triathlon. This new study definitely suggests that's a mistake.
http://well.blogs.nytimes.com/2009/09/01/phys-ed-does-ibuprofen-help-or-hurt-during-exercise/?em
Though it does do a pretty good job of taking care of aches and pains, perhaps taking painkillers is not a good idea.
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